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Dextran reduces embolic signals after carotid endarterectomy
Author(s) -
Levi Christopher R.,
Stork Jacinda L.,
Chambers Brian R.,
Abbott Anne L.,
Cameron Heather M.,
Peeters Anna,
Royle John P.,
Roberts Andrew K.,
Fell Gary,
Hoare Michael C.,
Chan Anthony T. W.,
Donnan Geoffrey A.
Publication year - 2001
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.1233
Subject(s) - carotid endarterectomy , dextran , medicine , placebo , dextran 70 , transcranial doppler , carotid arteries , anesthesia , endarterectomy , embolic stroke , intracranial embolism , cardiology , surgery , embolism , ischemia , ischemic stroke , pathology , biochemistry , chemistry , alternative medicine
One hundred fifty patients undergoing carotid endarterectomy were randomly assigned to receive intravenous 10% dextran 40 or placebo. Transcranial Doppler monitoring of the ipsilateral middle cerebral artery 0 to 1 hour postoperatively detected embolic signals in 57% of placebo and 42% of dextran patients, with overall embolic signal counts 46% less for dextran ( p = 0.052). Two to 3 hours postoperatively, embolic signals were present in 45% of placebo and 27% of dextran patients, with embolic signal counts 64% less for dextran ( p = 0.040). We conclude that dextran reduces embolic signals within 3 hours of CEA.