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Case‐control study of the extended tau gene haplotype in Parkinson's disease
Author(s) -
Maraganore Demetrius M.,
Hernandez Dena G.,
Singleton Andrew B.,
Farrer Matthew J.,
McDonnell Shan K.,
Hutton Michael L.,
Hardy John A.,
Rocca Walter A.
Publication year - 2001
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.1228
Subject(s) - progressive supranuclear palsy , odds ratio , haplotype , parkinson's disease , disease , degenerative disease , genotype , confidence interval , medicine , case control study , central nervous system disease , genetics , biology , gene
We investigated the association of Parkinson's disease with tau gene haplotypes. In a sample of 319 unrelated Parkinson's disease patients and 196 control subjects, we observed an increased risk of Parkinson's disease for persons with the H1/H1 genotype (odds ratio = 1.5; 95% confidence interval: 0.98–2.23); however, the finding was not statistically significant. The results remained similar after adjusting for the possible misclassification of progressive supranuclear palsy patients as Parkinson's disease, but became statistically significant after restricting the analysis to nondemented subjects.