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Proton magnetic resonance spectroscopy of brain metabolites in galactosemia
Author(s) -
Wang Zhiyue J.,
Berry Gerard T.,
Dreha Steffi F.,
Zhao Huaqing,
Segal Stanton,
Zimmerman Robert A.
Publication year - 2001
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.1102
Subject(s) - galactitol , galactosemia , medicine , endocrinology , excretion , proton magnetic resonance , chemistry , urinary system , nuclear magnetic resonance , galactose , biochemistry , physics
Brain edema may occur in infants with galactosemia and has been associated with accumulation of galactitol. Proton magnetic resonance spectra were obtained from 12 patients (four newly diagnosed neonates and eight patients on galactose‐restricted diets, age range 1.7–47 years) and control subjects to measure brain galactitol levels in vivo and correlate them with urinary galactitol excretion. The results demonstrate that a markedly elevated brain galactitol level may be present only in newborn infants with galactosemia who exhibit massive urinary galactitol excretion.