Premium
Brain dopamine‐stimulated adenylyl cyclase activity in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy
Author(s) -
Tong Junchao,
Fitzmaurice Paul S.,
Ang Lee Cyn,
Furukawa Yoshiaki,
Guttman Mark,
Kish Stephen J.
Publication year - 2004
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10814
Subject(s) - progressive supranuclear palsy , dopamine , levodopa , putamen , striatum , medicine , endocrinology , dopamine receptor , atrophy , dopamine receptor d2 , parkinson's disease , neuroscience , psychology , disease
The dopamine D 1 receptor is considered to participate in levodopa's antiparkinsonian action and levodopa‐induced dyskinesias. We examined the functional status of the D 1 receptor in brain of patients with Parkinson's disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP). Dopamine‐stimulated adenylyl cyclase activity was significantly increased in putamen (+43%) and frontal cortex (+52%) in PD, normal in PSP, but decreased by 47% in putamen in MSA. The supersensitive dopamine D 1 receptors in both striatum and cerebral cortex in PD might compensate for dopamine deficiency, but could also contribute to long‐term complications of levodopa therapy.