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Vascular parkinsonism in moyamoya: Microvascular biopsy and imaging correlates
Author(s) -
Tan EngKing,
Chan LingLing,
Yu Gui Xia,
Rumpel Helmut,
WilderSmith Einar,
Wong MengCheng
Publication year - 2003
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10783
Subject(s) - medicine , moyamoya disease , parkinsonism , muscle hypertrophy , stroke (engine) , cardiology , vascular smooth muscle , vascular disease , pathology , smooth muscle , disease , mechanical engineering , engineering
We highlight the first case to our knowledge of vascular parkinsonism with angiographic moyamoya and functional imaging correlates. In addition, transmission electron microscopy of the cutaneous vasculature revealed the mean smooth muscle cell layer of the terminal arterioles to be significantly higher compared with ischemic stroke patients classified by vascular risk factors. Smooth muscle cell thickness was also greater in those with small vessel and large vessel strokes compared with cardioembolic strokes. The marked cutaneous arteriolar smooth muscle cell hypertrophy may be a useful surrogate marker for those at risk of developing angiographic moyamoya.