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DJ‐1 colocalizes with tau inclusions: A link between parkinsonism and dementia
Author(s) -
Rizzu Patrizia,
Hinkle David A.,
Zhukareva Victoria,
Bonifati Vincenzo,
Severijnen LiesAnne,
Martinez Daniel,
Ravid Rivka,
Kamphorst Wouter,
Eberwine James H.,
Lee Virginia M.Y.,
Trojanowski John Q.,
Heutink Peter
Publication year - 2004
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10782
Subject(s) - parkinsonism , pathological , colocalization , dementia , tau protein , neuroscience , biology , pathology , medicine , genetics , alzheimer's disease , disease
Two novel mutations recently have been identified in the DJ‐1 gene that cause a new form of autosomal recessive, early‐onset parkinsonism. Because the pathological role of this protein is unknown, we examined the issue here and report the colocalization of DJ‐1 protein within a subset of pathological tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies. Our study extends the view that different neurodegenerative diseases may have similar pathological mechanisms, and that these processes likely include DJ‐1.