z-logo
Premium
DJ‐1 colocalizes with tau inclusions: A link between parkinsonism and dementia
Author(s) -
Rizzu Patrizia,
Hinkle David A.,
Zhukareva Victoria,
Bonifati Vincenzo,
Severijnen LiesAnne,
Martinez Daniel,
Ravid Rivka,
Kamphorst Wouter,
Eberwine James H.,
Lee Virginia M.Y.,
Trojanowski John Q.,
Heutink Peter
Publication year - 2004
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10782
Subject(s) - parkinsonism , pathological , colocalization , dementia , tau protein , neuroscience , biology , pathology , medicine , genetics , alzheimer's disease , disease
Two novel mutations recently have been identified in the DJ‐1 gene that cause a new form of autosomal recessive, early‐onset parkinsonism. Because the pathological role of this protein is unknown, we examined the issue here and report the colocalization of DJ‐1 protein within a subset of pathological tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies. Our study extends the view that different neurodegenerative diseases may have similar pathological mechanisms, and that these processes likely include DJ‐1.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here