Premium
Functional neuroimaging provides evidence of anomalous cerebral laterality in adults with Klinefelter's syndrome
Author(s) -
Itti Emmanuel,
Gaw Gonzalo Irene T.,
Boone Kyle B.,
Geschwind Daniel H.,
Berman Nancy,
PawlikowskaHaddal Anna,
Itti Laurent,
Mishkin Fred S.,
Swerdloff Ronald S.
Publication year - 2003
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10735
Subject(s) - laterality , neuroimaging , klinefelter syndrome , functional neuroimaging , psychology , neuroscience , medicine
This study aimed to characterize cerebral perfusion in men with Klinefelter's syndrome, known to present specific deficits in language, using 99m Tc‐ hexamethylpropylene‐amine‐oxime scintigraphy and Talairach normalization. While a perfusion asymmetry toward the left hemisphere was found in controls, perfusion was mostly symmetrical in Klinefelter patients in the upper temporal and lower parietal areas. Scores on verbal tests were inversely correlated with perfusion changes, providing neurobiological substrate of anomalous cerebral laterality.