Premium
A diagnostic cycle test for McArdle's disease
Author(s) -
Vissing John,
Haller Ronald G.
Publication year - 2003
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10725
Subject(s) - pathognomonic , medicine , heart rate , exertion , cardiology , workload , heart disease , perceived exertion , physical therapy , disease , cycle ergometer , blood pressure , computer science , operating system
We investigated whether the second wind phenomenon (ie, a decrease in heart rate and perceived exertion during exercise) is pathognomonic for McArdle's disease. Twenty‐four patients with McArdle's disease, 17 healthy subjects, and 25 patients with other inborn errors of muscle metabolism cycled a constant workload for 15 minutes. In McArdle's disease patients, heart rate consistently decreased by 35 ± 3 beats per minute from the 7 th to the 15 th minute of exercise, whereas heart rate increased progressively with exercise in all 42 control subjects. The findings indicate that cycling at a moderate, constant workload provides a specific, sensitive, and simple diagnostic test for McArdle's disease. Ann Neurol 2003;54:539‐542