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Voltage‐gated potassium channel antibodies in limbic encephalitis
Author(s) -
PozoRosich Patricia,
Clover Linda,
Saiz Albert,
Vincent Angela,
Graus Francesc
Publication year - 2003
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10713
Subject(s) - limbic encephalitis , immunotherapy , medicine , antibody , cancer , potassium channel , immunology , pathology , autoantibody
We found voltage‐gated potassium channel (VGKC) antibodies in 4 of 15 patients with limbic encephalitis (LE). Two patients with idiopathic LE had high VGKC antibody levels (>800pM; controls <100pM), that fell in parallel with a clinical response to immunotherapy. Two patients with lower VGKC antibodies (170pM, 300pM) had lung cancer (radiological evidence only in one) and the LE improved with immunotherapy in one. The other 11 patients without VGKC antibodies had paraneoplastic LE and eight onconeural antibodies (Hu in 6; Ma2 in 2). VGKC antibodies do not unambiguously discriminate between idiopathic or paraneoplastic LE but probably indicate a good response to immunotherapy. Ann Neurol 2003;54:530‐533