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Subthalamic nucleus stimulation affects a frontotemporal network: A PET study
Author(s) -
Schroeder Ulrike,
Kuehler Andreas,
Lange Klaus W.,
Haslinger Bernhard,
Tronnier Volker M.,
Krause Martin,
Pfister Robert,
Boecker Henning,
CeballosBaumann Andres O.
Publication year - 2003
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10683
Subject(s) - deep brain stimulation , subthalamic nucleus , verbal fluency test , frontotemporal dementia , psychology , neuroscience , stimulation , neuropsychology , fluency , medicine , parkinson's disease , audiology , disease , cognition , dementia , mathematics education
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become an effective strategy in the treatment of motor symptoms in advanced Parkinson's disease. However, clinical studies have shown that DBS can affect verbal fluency. Seven Parkinson's disease patients with bilateral DBS of the STN were studied with positron emission tomography (PET) to investigate the effects of STN stimulation on regional cerebral blood flow during a verbal fluency task. Activation of the right orbitofrontal cortex and verbal fluency‐associated activation within a left‐sided frontotemporal network were decreased during STN stimulation compared with the OFF state. Our results offer an explanation for the commonest neuropsychological side effect of STN stimulation and show that STN stimulation affects a frontotemporal network during a fluency task. Ann Neurol 2003;54:000–000