Premium
Herpesviruses in brains in Alzheimer's and Parkinson's diseases
Author(s) -
Hemling Niina,
Röyttä Matias,
Rinne Juha,
Pöllänen Paju,
Broberg Eeva,
Tapio Virpi,
Vahlberg Tero,
Hukkanen Veijo
Publication year - 2003
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10662
Subject(s) - polymerase chain reaction , dna , hsl and hsv , herpesviridae , virology , medicine , immunology , disease , parkinson's disease , virus , biology , viral disease , pathology , gene , genetics
We evaluated the association of HSV‐1, HHV‐6, and VZV with Alzheimer's disease (AD) and Parkinson's disease (PD). Brain specimens for viral DNA polymerase chain reaction represented 34 patients with AD, 40 with PD, and 40 controls. One AD patient (2.9%) was positive for HSV‐1 DNA, 88.2% for HHV‐6 DNA, and 26.5% for VZV DNA; 17.5% of PD patients were HSV‐1 DNA–positive and 75% HHV‐6–positive, whereas 40% had VZV DNA. Twenty‐five percent of the controls were positive for HSV‐1 DNA, 87.5% for HHV‐6, and 27.5% for VZV. HSV‐1, VZV, or HHV‐6 DNA in brains was no additional risk factor for AD.