Premium
Cerebrospinal fluid sulfatide is decreased in subjects with incipient dementia
Author(s) -
Han Xianlin,
Fagan Anne M.,
Cheng Hua,
Morris John C.,
Xiong Chengjie,
Holtzman David M.
Publication year - 2003
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10618
Subject(s) - cerebrospinal fluid , dementia , alzheimer's disease , biomarker , medicine , degenerative disease , phosphatidylinositol , disease , pathology , chemistry , biochemistry , kinase
We recently noted a profound decline in brain sulfatides (ST) in subjects who died with incipient dementia due to Alzheimer's disease. Herein, we measured ST levels in cerebrospinal fluid in cognitively normal elderly and in subjects with mild cognitive impairment due to incipient demenia of the Alzheimer type. There was a significant decrease in cerebrospinal fluid ST and in the ST to phosphatidylinositol ratio in MCI subjects. The ST to phosphatidylinositol ratio accurately differentiated very mildly impaired subjects from controls on an individual basis. The cerebrospinal fluid ST to phosphatidylinositol ratio may be a very useful biomarker for the earliest clinical stage of Alzheimer's disease. Ann Neurol 2003;54:115–119