Premium
Genetic interaction of CTLA‐4 with HLA‐DR15 in multiple sclerosis patients
Author(s) -
Alizadeh Mehdi,
Babron MarieClaude,
Birebent Brigitte,
Matsuda Fumihiko,
Quelvennec Erwann,
Liblau Roland,
CournuRebeix Isabelle,
MomiglianoRichiardi Patricia,
Sequeiros Jorge,
Yaouanq Jacqueline,
Genin Emmanuelle,
Vasilescu Alexandre,
Bougerie Héloise,
Trojano Maria,
Martins Silva Berta,
Maciel Patricia,
ClergetDarpoux Françoise,
Clanet Michel,
Edan Gilles,
Fontaine Bertrand,
Semana Gilbert
Publication year - 2003
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10617
Subject(s) - multiple sclerosis , human leukocyte antigen , haplotype , major histocompatibility complex , histocompatibility , genetic predisposition , immunology , disease , gene , genetics , biology , medicine , allele , antigen , pathology
Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component. Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA‐DRB1*1501‐DQB1*0602 haplotype. In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte‐associated antigen 4 ( CTLA‐4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility. Our data were obtained from two European independent family‐based studies including 610 multiple sclerosis family trios. Ann Neurol 2003;54:119–122