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Elevated osteopontin levels in active relapsing‐remitting multiple sclerosis
Author(s) -
Vogt Mario H. J.,
Lopatinskaya Luba,
Smits Monique,
Polman Chris H.,
Nagelkerken Lex
Publication year - 2003
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10606
Subject(s) - osteopontin , multiple sclerosis , pathogenesis , relapsing remitting , medicine , cytokine , immunology , clinically isolated syndrome
In the search for proteins that might play a role in the pathogenesis of multiple sclerosis (MS), osteopontin (OPN) has been identified as the most prominent cytokine‐encoding gene expressed within MS lesions. Here, we report significantly increased OPN protein levels in plasma of relapsing‐remitting MS patients. In contrast, OPN protein levels in primary progressive and secondary progressive MS patients were similar to healthy control levels. Interestingly, active relapsing‐remitting patients had higher OPN protein levels than patients without relapses. Ann Neurol 2003;53:819–822