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Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis
Author(s) -
Kirkinezos Ilias G.,
Hernandez Dayami,
Bradley Walter G.,
Moraes Carlos T.
Publication year - 2003
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10597
Subject(s) - amyotrophic lateral sclerosis , sod1 , regimen , genetically modified mouse , medicine , life span , physical medicine and rehabilitation , animal model , treadmill , psychology , neuroscience , transgene , gerontology , biology , disease , genetics , gene
Abstract We tested whether a regular exercise regimen was associated with a change in the life span of G93A‐SOD1 transgenic mice, a model of familial ALS. Regular treadmill running for 10 weeks led to a significant increase in the life span of G93A‐SOD1 mice. The effect was stronger in male mice, whereas there was only a trend between exercised and sedentary female G93A‐SOD1 mice. The data suggest that regular exercise has a beneficial effect on the progression of ALS. Ann Neurol 2003;53:804–807