Premium
Slowing of voluntary and involuntary saccades: An early sign in spinocerebellar ataxia type 7
Author(s) -
Oh Andrew K.,
Jacobson Kathleen M.,
Jen Joanna C.,
Baloh Robert W.
Publication year - 2001
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.1059
Subject(s) - spinocerebellar ataxia , subclinical infection , asymptomatic , audiology , ataxia , eye movement , asymptomatic carrier , brainstem , psychology , smooth pursuit , medicine , ophthalmology , neuroscience
We describe quantitative oculomotor findings in a patient with subclinical spinocerebellar ataxia type 7 (SCA7) and a borderline mutation of 38 CAG repeats and her daughter with SCA7 and 46 repeats. Both subjects demonstrated significant slowing of voluntary and involuntary saccades, but retinal examination was normal. Smooth pursuit and fixation suppression of VOR were mildly impaired. Slow saccades may be the earliest neurologic finding even in asymptomatic SCA7 patients with normal ocular fundi. The SCA7 mutation probably has an early impact on brainstem fast eye movement centers.