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Functional magnetic resonance imaging of human absence seizures
Author(s) -
SalekHaddadi Afraim,
Lemieux Louis,
Merschhemke Martin,
Friston Karl J.,
Duncan John S.,
Fish David R.
Publication year - 2003
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10586
Subject(s) - functional magnetic resonance imaging , magnetic resonance imaging , epilepsy , neuroscience , electroencephalography , magnetoencephalography , medicine , thalamus , psychology , nuclear magnetic resonance , radiology , physics
We studied a patient with idiopathic generalized epilepsy and frequent absences, using electroencephalogram‐correlated functional magnetic resonance imaging. Four prolonged runs of generalized spike‐wave discharge occurred during a 35‐minute experiment. Time‐locked activation was observed bilaterally within the thalami in conjunction with widespread but symmetrical cortical deactivation with a frontal maximum. We demonstrate the reciprocal participation of focal thalamic and widespread cortical networks during human absence seizures and suggest reductions in cortical blood flow, in response to synchronized electroencephalogram activity. Ann Neurol 2003;53:663–667