New T2 lesions enable an earlier diagnosis of multiple sclerosis in clinically isolated syndromes | Zendy

Dalton Catherine M. | Zendy; Brex Peter A. | Zendy; Miszkiel Katherine A. | Zendy; Fernando Kryshani | Zendy; MacManus David G. | Zendy; Plant Gordon T. | Zendy; Thompson Alan J. | Zendy; Miller David H. | Zendy

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New T2 lesions enable an earlier diagnosis of multiple sclerosis in clinically isolated syndromes

Author(s) -

Dalton Catherine M.,

Brex Peter A.,

Miszkiel Katherine A.,

Fernando Kryshani,

MacManus David G.,

Plant Gordon T.,

Thompson Alan J.,

Miller David H.

Publication year - 2003

Publication title -

annals of neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.764

H-Index - 296

eISSN - 1531-8249

pISSN - 0364-5134

DOI - 10.1002/ana.10580

Subject(s) - multiple sclerosis , medicine , magnetic resonance imaging , cohort , clinically isolated syndrome , gadolinium , t2 weighted , radiology , immunology , materials science , metallurgy

In clinically isolated syndromes, the new McDonald criteria for multiple sclerosis diagnosis require new gadolinium‐enhancing lesions for dissemination in time at a 3‐month follow‐up magnetic resonance imaging scan. In a cohort of 56 patients, these criteria were specific (95%) but less sensitive (58%) for clinically definite multiple sclerosis at 3 years. If new T2 lesions were allowed as an alternative for dissemination in time, sensitivity increased (74%) with maintained specificity (92%), enabling an accurate diagnosis of multiple sclerosis in more patients. Ann Neurol 2003;53:673–676

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