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New T2 lesions enable an earlier diagnosis of multiple sclerosis in clinically isolated syndromes
Author(s) -
Dalton Catherine M.,
Brex Peter A.,
Miszkiel Katherine A.,
Fernando Kryshani,
MacManus David G.,
Plant Gordon T.,
Thompson Alan J.,
Miller David H.
Publication year - 2003
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10580
Subject(s) - multiple sclerosis , medicine , magnetic resonance imaging , cohort , clinically isolated syndrome , gadolinium , t2 weighted , radiology , immunology , materials science , metallurgy
In clinically isolated syndromes, the new McDonald criteria for multiple sclerosis diagnosis require new gadolinium‐enhancing lesions for dissemination in time at a 3‐month follow‐up magnetic resonance imaging scan. In a cohort of 56 patients, these criteria were specific (95%) but less sensitive (58%) for clinically definite multiple sclerosis at 3 years. If new T2 lesions were allowed as an alternative for dissemination in time, sensitivity increased (74%) with maintained specificity (92%), enabling an accurate diagnosis of multiple sclerosis in more patients. Ann Neurol 2003;53:673–676