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Weight loss in Parkinson's disease
Author(s) -
Chen Honglei,
Zhang Shumin M.,
Hernán Miguel A.,
Willett Walter C.,
Ascherio Alberto
Publication year - 2003
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10577
Subject(s) - parkinson's disease , weight loss , medicine , disease , body weight , energy expenditure , gastroenterology , pediatrics , obesity
We prospectively examined the changes of body weight among 468 individuals with Parkinson's disease (PD) before and after the diagnosis. The average weight of PD patients was stable until shortly before the diagnosis ( p for trend = 0.2) and then declined ( p for trend < 0.0001). Interestingly, PD patients tended to increase their energy intakes as their weights decreased ( p for trend < 0.002). In conclusion, weight loss in PD patients appears to be a continuous process that starts several years before the diagnosis and is not caused by reduced energy intake. Ann Neurol 2003;53:676–679