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Cortical anomalies associated with visuospatial processing deficits
Author(s) -
Isaacs Elizabeth B.,
Edmonds Caroline J.,
Chong Wui K.,
Lucas Alan,
Gadian David G.
Publication year - 2003
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10546
Subject(s) - white matter , magnetic resonance imaging , neuroscience , psychology , context (archaeology) , extrastriate cortex , voxel , functional magnetic resonance imaging , orientation (vector space) , voxel based morphometry , visual cortex , medicine , biology , radiology , geometry , mathematics , paleontology
Children born preterm provide a fruitful population for studying structure–function relationships because they often have specific functional deficits in the context of normal neurological status. We selected a group of preterm adolescents with deficits in judgment of line orientation. Despite their very low birth weight, all were neurologically normal with no consistent abnormalities on conventional magnetic resonance imaging. However, voxel‐based morphometric analysis of their magnetic resonance imaging scans showed areas of decreased gray matter and increased white matter most prominently in right ventral extrastriate cortex, close to an area previously implicated in the line orientation task. We suggest that these anomalies of cortical architecture relate to impaired performance on the line orientation task. Ann Neurol 2003;53:768–773