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A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions
Author(s) -
Bitsch Andreas,
Kuhlmann Tanja,
Stadelmann Christine,
Lassmann Hans,
Lucchinetti Claudia,
Brück Wolfgang
Publication year - 2001
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.1053
Subject(s) - multiple sclerosis , medicine , lesion , pathology , magnetic resonance imaging , central nervous system disease , radiology , surgery , psychiatry
Severe tissue destruction is the presumed histopathological correlate of hypointense multiple sclerosis (MS) lesions. In this study we correlated changes of lesion hypointensity over time with initial histopathological features in 14 biopsied MS lesions. The extent of hypointensity increased in initially demyelinated plaques and decreased in remyelinating lesions. The initial axonal loss determined the increase of hypointensity over time. In conclusion, both axonal loss and demyelinating activity determine the evolution of hypointensity over time.