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Diminished striatal [ 123 I]iodobenzovesamicol binding in idiopathic cervical dystonia
Author(s) -
Albin Roger L.,
Cross Donna,
Cornblath Wayne T.,
Wald John A.,
Wernette Kristine,
Frey Kirk A.,
Minoshima Satoshi
Publication year - 2003
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10527
Subject(s) - cervical dystonia , striatum , dystonia , neuroscience , cholinergic , medicine , single photon emission computed tomography , interneuron , endocrinology , psychology , dopamine , inhibitory postsynaptic potential
Striatal dysfunction is thought to underlie many dystonias. We used [ 123 I]iodobenzovesamicol single‐photon emission computed tomography imaging to determine the density of cholinergic terminals in the striatum and other brain regions in 13 subjects with idiopathic cervical dystonia. Striatal [ 131 I]iodobenzovesamicol binding was reduced. These results support a role for striatal dysfunction in idiopathic dystonias and suggest diminished striatal cholinergic interneuron density in cervical dystonia. Ann Neurol 2003;53:528–532