Diminished striatal [ 123 I]iodobenzovesamicol binding in idiopathic cervical dystonia | Zendy

Albin Roger L. | Zendy; Cross Donna | Zendy; Cornblath Wayne T. | Zendy; Wald John A. | Zendy; Wernette Kristine | Zendy; Frey Kirk A. | Zendy; Minoshima Satoshi | Zendy

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Diminished striatal [ 123 I]iodobenzovesamicol binding in idiopathic cervical dystonia

Author(s) -

Albin Roger L.,

Cross Donna,

Cornblath Wayne T.,

Wald John A.,

Wernette Kristine,

Frey Kirk A.,

Minoshima Satoshi

Publication year - 2003

Publication title -

annals of neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.764

H-Index - 296

eISSN - 1531-8249

pISSN - 0364-5134

DOI - 10.1002/ana.10527

Subject(s) - cervical dystonia , striatum , dystonia , neuroscience , cholinergic , medicine , single photon emission computed tomography , interneuron , endocrinology , psychology , dopamine , inhibitory postsynaptic potential

Striatal dysfunction is thought to underlie many dystonias. We used [ 123 I]iodobenzovesamicol single‐photon emission computed tomography imaging to determine the density of cholinergic terminals in the striatum and other brain regions in 13 subjects with idiopathic cervical dystonia. Striatal [ 131 I]iodobenzovesamicol binding was reduced. These results support a role for striatal dysfunction in idiopathic dystonias and suggest diminished striatal cholinergic interneuron density in cervical dystonia. Ann Neurol 2003;53:528–532

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