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Hippocampal sclerosis is a progressive disorder: A longitudinal volumetric MRI study
Author(s) -
Fuerst Darren,
Shah Jagdish,
Shah Aashit,
Watson Craig
Publication year - 2003
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10509
Subject(s) - hippocampal formation , hippocampal sclerosis , temporal lobe , epilepsy , magnetic resonance imaging , atrophy , medicine , hippocampus , refractory (planetary science) , mesial temporal lobe epilepsy , neuroscience , psychology , pathology , radiology , physics , astrobiology
Twelve patients with refractory temporal lobe epilepsy and unilateral hippocampal sclerosis had repeat volumetric magnetic resonance imaging scans after a mean of 3.4 years to determine whether progressive hippocampal volume loss occurred. Seizure‐free patients showed no change in hippocampal volume. Patients with continuing seizures had a decline in ipsilateral hippocampal volume that correlated with seizure frequency. Patients with medically refractory temporal lobe epilepsy and unilateral hippocampal sclerosis have progressive hippocampal atrophy. Ann Neurol 2003;53:413–416