Hippocampal sclerosis is a progressive disorder: A longitudinal volumetric MRI study | Zendy

Fuerst Darren | Zendy; Shah Jagdish | Zendy; Shah Aashit | Zendy; Watson Craig | Zendy

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Hippocampal sclerosis is a progressive disorder: A longitudinal volumetric MRI study

Author(s) -

Fuerst Darren,

Shah Jagdish,

Shah Aashit,

Watson Craig

Publication year - 2003

Publication title -

annals of neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.764

H-Index - 296

eISSN - 1531-8249

pISSN - 0364-5134

DOI - 10.1002/ana.10509

Subject(s) - hippocampal formation , hippocampal sclerosis , temporal lobe , epilepsy , magnetic resonance imaging , atrophy , medicine , hippocampus , refractory (planetary science) , mesial temporal lobe epilepsy , neuroscience , psychology , pathology , radiology , physics , astrobiology

Twelve patients with refractory temporal lobe epilepsy and unilateral hippocampal sclerosis had repeat volumetric magnetic resonance imaging scans after a mean of 3.4 years to determine whether progressive hippocampal volume loss occurred. Seizure‐free patients showed no change in hippocampal volume. Patients with continuing seizures had a decline in ipsilateral hippocampal volume that correlated with seizure frequency. Patients with medically refractory temporal lobe epilepsy and unilateral hippocampal sclerosis have progressive hippocampal atrophy. Ann Neurol 2003;53:413–416

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