PRNP Val129 homozygosity increases risk for early‐onset Alzheimer's disease | Zendy

Dermaut Bart | Zendy; Croes Esther A. | Zendy; Rademakers Rosa | Zendy; Van Den Broeck Marleen | Zendy; Cruts Marc | Zendy; Hofman Albert | Zendy; Van Duijn Cornelia M. | Zendy; Van Broeckhoven Christine | Zendy

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PRNP Val129 homozygosity increases risk for early‐onset Alzheimer's disease

Author(s) -

Dermaut Bart,

Croes Esther A.,

Rademakers Rosa,

Van Den Broeck Marleen,

Cruts Marc,

Hofman Albert,

Van Duijn Cornelia M.,

Van Broeckhoven Christine

Publication year - 2003

Publication title -

annals of neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.764

H-Index - 296

eISSN - 1531-8249

pISSN - 0364-5134

DOI - 10.1002/ana.10507

Subject(s) - odds ratio , prnp , confidence interval , medicine , disease , alzheimer's disease , prion protein

We analyzed the PRNP M129V polymorphism in a Dutch population‐based early‐onset Alzheimer's disease sample. We observed a significant association between early‐onset Alzheimer's disease and homozygosity of M129V (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.1–3.3; p = 0.02) with the highest risk for V homozygotes (OR, 3.2; 95% CI, 1.4–7.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.3–5.3; p < 0.01) and 3.5 (95% CI, 1.3–9.3; p = 0.01), respectively. Ann Neurol 2003;53;409–412

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