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PRNP Val129 homozygosity increases risk for early‐onset Alzheimer's disease
Author(s) -
Dermaut Bart,
Croes Esther A.,
Rademakers Rosa,
Van Den Broeck Marleen,
Cruts Marc,
Hofman Albert,
Van Duijn Cornelia M.,
Van Broeckhoven Christine
Publication year - 2003
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10507
Subject(s) - odds ratio , prnp , confidence interval , medicine , disease , alzheimer's disease , prion protein
We analyzed the PRNP M129V polymorphism in a Dutch population‐based early‐onset Alzheimer's disease sample. We observed a significant association between early‐onset Alzheimer's disease and homozygosity of M129V (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.1–3.3; p = 0.02) with the highest risk for V homozygotes (OR, 3.2; 95% CI, 1.4–7.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.3–5.3; p < 0.01) and 3.5 (95% CI, 1.3–9.3; p = 0.01), respectively. Ann Neurol 2003;53;409–412