Premium
Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS
Author(s) -
Zhang Wenhua,
Narayanan Malini,
Friedlander Robert M.
Publication year - 2003
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10476
Subject(s) - neuroprotection , minocycline , amyotrophic lateral sclerosis , creatine , medicine , pharmacology , neuroscience , chemistry , psychology , biochemistry , antibiotics , disease
Abstract The known neuroprotective effects of minocycline and creatine in animal models of amyotrophic lateral sclerosis (ALS) led us to examine whether the combination of these agents would result in increased neuroprotection. As previously reported, we confirmed in ALS mice that either minocycline or creatine treatment results in improvement in motor performance and extended survival. We report that combination of minocycline and creatine resulted in additive neuroprotection, suggesting this to be a novel potential strategy for the treatment of ALS. To our knowledge, this is the first report demonstrating additive neuroprotection of a combinatorial approach in a mouse model of ALS. Adding relevancy to our findings, minocycline and creatine, are relatively safe, cross the blood–brain barrier, and are currently available for human evaluation.