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Meningioma presenting with Cushing's syndrome: An unusual clinical presentation
Author(s) -
Pecori Giraldi Francesca,
Terreni Maria Rosa,
Andreotti Claudia,
Losa Marco,
Lanzi Roberto,
Pontiroli Antonio E.,
Cavagnini Francesco
Publication year - 2003
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10454
Subject(s) - meningioma , presentation (obstetrics) , cushing syndrome , medicine , corticotropin releasing hormone , concomitant , hormone , endocrinology , pathology , radiology
We report a patient with a meningioma presenting with Cushing's syndrome, an unprecedented paraneoplastic presentation. Molecular studies, bioassay, and high‐performance liquid chromatography of tumor specimens demonstrated the synthesis and secretion of bioactive corticotropin‐releasing hormone. To our knowledge, this appears to be the first report of a hormone‐secreting meningioma and, further, the first clearly proven case of Cushing's syndrome due to ectopic corticotropin‐releasing hormone secretion without concomitant corticotropin production. Ann Neurol 2003