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Association of chromosome 10 losses and negative prognosis in oligoastrocytomas
Author(s) -
Bissola Lorena,
Eoli Marica,
Pollo Bianca,
Merciai Bianca Maria,
Silvani Antonio,
Salsano Ettore,
Maccagnano Carmelo,
Bruzzone Maria Grazia,
Fuhrman Conti Anna Maria,
Solero Carlo Lazzaro,
Giombini Sergio,
Broggi Giovanni,
Boiardi Amerigo,
Finocchiaro Gaetano
Publication year - 2002
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10405
Subject(s) - loss of heterozygosity , biology , chromosome , oncology , medicine , genetics , gene , allele
Abstract Oligoastrocytomas are mixed gliomas harboring different genetic alterations and with heterogeneous clinical evolution. We have looked for correlations between genetic losses and clinical evolution in 34 oligoastrocytomas. Loss of heterozygosity (LOH) with different microsatellite markers was studied on chromosomes 1p, 10q, 17p, and 19q. LOH on 1p was found in 44% of the tumors, on 10q in 24%, on 17p in 18%, and on 19q in 38%. LOH on 1p and 19q was combined in 29% of the patients. LOH on 1p was associated with significantly longer overall survival ( p = 0.0092) and LOH on 10q with shorter overall survival ( p = 0.0206). The observation that LOH on 10q predicts a short survival in oligoastrocytomas is novel and provides further evidence that genetic analysis may help to predict the clinical evolution of different gliomas, giving a more rationale basis to therapeutic options.