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Loss of myostatin attenuates severity of muscular dystrophy in mdx mice
Author(s) -
Wagner Kathryn R.,
McPherron Alexandra C.,
Winik Nicole,
Lee SeJin
Publication year - 2002
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10385
Subject(s) - myostatin , duchenne muscular dystrophy , muscular dystrophy , mdx mouse , skeletal muscle , medicine , fibrosis , endocrinology , regeneration (biology) , biology , transforming growth factor , regulator , dystrophin , microbiology and biotechnology , gene , genetics
Myostatin, a transforming growth factor–β family member, is a negative regulator of skeletal muscle growth. To explore the therapeutic potential of targeting myostatin in settings of muscle degeneration, we crossed myostatin null mutant mice with mdx mice, a model for Duchenne and Becker muscular dystrophy. Mdx mice lacking myostatin were stronger and more muscular than their mdx counterparts. Diaphragm muscle showed less fibrosis and fatty remodeling, suggesting improved muscle regeneration.