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Disruption of the proprioceptive mapping in the medial wall of parkinsonian monkeys
Author(s) -
Escola Ludovic,
Michelet Thomas,
Douillard Gaelle,
Guehl Dominique,
Bioulac Bernard,
Burbaud Pierre
Publication year - 2002
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10337
Subject(s) - proprioception , neuroscience , mptp , psychology , motor cortex , physical medicine and rehabilitation , dopamine , medicine , dopaminergic , stimulation
Parkinsonian patients present an impairment of proprioceptor‐guided movement that could imply abnormal processing in the frontal mesial cortex. To test this hypothesis, we compared neuronal response to joint displacement in the supplementary and presupplementary motor areas of two monkeys, before and after the progressive establishment of an 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)–induced parkinsonian syndrome. After MPTP administration, neurons were activated by the passive movement of numerous joints in various directions and no longer simply by one or two joints in one direction. This impairment of the focused selection of proprioceptive inputs, imputable to dopamine depletion, could impede motor planning and thus contribute to akinesia.