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Clasmatodendrosis correlating with periventricular hyperintensity in mixed dementia
Author(s) -
Sahlas Demetrios J.,
Bilbao Juan M.,
Swartz Richard H.,
Black Sandra E.
Publication year - 2002
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10310
Subject(s) - hyperintensity , pathology , white matter , dementia , leukoaraiosis , magnetic resonance imaging , medicine , alzheimer's disease , disease , psychology , radiology
We report a 79‐year‐old woman with possible Alzheimer's disease and confluent periventricular white matter hyperintensities on magnetic resonance imaging in whom postmortem analysis unexpectedly demonstrated no periventricular demyelination or cerebral arteriosclerosis. However, astrocytes in the periventricular white matter exhibited clasmatodendrosis, defined as cytoplasmic swelling and vacuolation of astroglia, with beading of their dendrites. This finding represents a previously unrecognized correlate of periventricular white matter hyperintensities. Ann Neurol 2002;52:378–381