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Increased urine phenylethylamine after methylphenidate treatment in children with ADHD
Author(s) -
Kusaga Akira,
Yamashita Yushiro,
Koeda Tastuya,
Hiratani Michio,
Kaneko Mika,
Yamada Shigeto,
Matsuishi Toyojiro
Publication year - 2002
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10302
Subject(s) - methylphenidate , homovanillic acid , neurochemical , attention deficit hyperactivity disorder , dopamine , urine , medicine , psychology , psychiatry , serotonin , receptor
The urine levels of β‐phenylethylamine, 3‐methoxy‐4‐hydroxyphenyl glycol, homovanillic acid, and 5‐hydroxyindoleacetic acid were measured to clarify the neurochemical mechanism in attention deficit hyperactivity disorder. β‐Phenylethylamine levels were significantly lower in attention deficit hyperactivity disorder individuals (n = 37) than in controls (n = 21). The 22 children with attention deficit hyperactivity disorder were treated with methylphenidate, and they were further divided into methylphenidate responders (n = 18) and nonresponders (n = 4). β‐Phenylethylamine levels significantly increased after methylphenidate therapy in responders, whereas they did not increase in nonresponders.