Parkinson's disease is not associated with the combined α‐synuclein/apolipoprotein E susceptibility genotype | Zendy

Khan Naheed | Zendy; Graham Elizabeth | Zendy; Dixon Peter | Zendy; Morris Christopher | Zendy; Mander Adrian | Zendy; Clayton David | Zendy; Vaughan J. | Zendy; Quinn Niall | Zendy; Lees Andrew | Zendy; Daniel Susan | Zendy; Wood Nicholas | Zendy; De Silva Rohan | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Parkinson's disease is not associated with the combined α‐synuclein/apolipoprotein E susceptibility genotype

Author(s) -

Khan Naheed,

Graham Elizabeth,

Dixon Peter,

Morris Christopher,

Mander Adrian,

Clayton David,

Vaughan J.,

Quinn Niall,

Lees Andrew,

Daniel Susan,

Wood Nicholas,

De Silva Rohan

Publication year - 2001

Publication title -

annals of neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.764

H-Index - 296

eISSN - 1531-8249

pISSN - 0364-5134

DOI - 10.1002/ana.1027

Subject(s) - genotype , apolipoprotein e , parkinson's disease , allele , disease , degenerative disease , alpha synuclein , synuclein , polymorphism (computer science) , genetics , biology , medicine , pathology , gene

A recent study showed significant association of sporadic Parkinson's disease with a polymorphism within the α‐synuclein gene and closely linked DNA markers on chromosome 4q and the APOE ε4 allele. A combined α‐synuclein/ APOE‐ ε4 genotype increased the relative risk of developing Parkinson's disease 12‐fold. We failed to confirm this association in a much larger sample of histopathologically proven cases of Parkinson's disease and controls.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research