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Parkinson's disease is not associated with the combined α‐synuclein/apolipoprotein E susceptibility genotype
Author(s) -
Khan Naheed,
Graham Elizabeth,
Dixon Peter,
Morris Christopher,
Mander Adrian,
Clayton David,
Vaughan J.,
Quinn Niall,
Lees Andrew,
Daniel Susan,
Wood Nicholas,
De Silva Rohan
Publication year - 2001
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.1027
Subject(s) - genotype , apolipoprotein e , parkinson's disease , allele , disease , degenerative disease , alpha synuclein , synuclein , polymorphism (computer science) , genetics , biology , medicine , pathology , gene
A recent study showed significant association of sporadic Parkinson's disease with a polymorphism within the α‐synuclein gene and closely linked DNA markers on chromosome 4q and the APOE ε4 allele. A combined α‐synuclein/ APOE‐ ε4 genotype increased the relative risk of developing Parkinson's disease 12‐fold. We failed to confirm this association in a much larger sample of histopathologically proven cases of Parkinson's disease and controls.