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Preferential loss of paternal 19q, but not 1p, alleles in oligodendrogliomas
Author(s) -
Sanson Marc,
Leuraud Pascal,
Marie Yannick,
Delattre JeanYves,
HoangXuan Khê
Publication year - 2002
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10217
Subject(s) - allele , oligodendroglioma , biology , genetics , suppressor , genomic imprinting , gene , tumor suppressor gene , loss of heterozygosity , glioma , carcinogenesis , dna methylation , gene expression , astrocytoma
Portions of chromosomes 1p and 19q, which are frequently deleted in oligodendrogliomas, are subject to genomic imprinting, suggesting that the putative tumor suppressor genes could be monoallelically expressed. The parental origins of 1p and 19q allele losses were determined in 6 cases of pure oligodendroglioma. An equilibrated parental loss (3 maternal and 3 paternal) was found for 1p deletions. In contrast, 19q deletions always occurred on the paternal copy ( p = 0.015). In this setting, a cloning strategy based on a search for homozygous deletion or mutation of the remaining allele would be appropriate for identifying the tumor suppressor gene located on 1p but inappropriate for identifying the presumably monoallelically expressed tumor suppressor gene located on 19q.