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High headache prevalence among women with hemochromatosis: The Nord‐Trøndelag health study
Author(s) -
Hagen Knut,
Stovner Lars Jacob,
Åsberg Arne,
Thorstensen Ketil,
Bjerve Kristian S.,
Hveem Kristian
Publication year - 2002
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10209
Subject(s) - medicine , hemochromatosis , pediatrics , environmental health
In this large cross‐sectional population‐based study, 51,272 persons responded to a headache questionnaire and were screened for hemochromatosis. Phenotypic hemochromatosis and the C282Y/C282Y genotype were both associated with an 80% increase in headache prevalence evident only among women. The reason for this association is unclear, but one may speculate that iron overload alters the threshold for triggering a headache by disturbing neuronal function.