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Subclinical cerebellar impairment in the common types of migraine: A three‐dimensional analysis of reaching movements
Author(s) -
Sándor Peter S.,
Mascia Addolorata,
Seidel Laurence,
De Pasqua Victor,
Schoenen Jean
Publication year - 2001
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.1019
Subject(s) - familial hemiplegic migraine , migraine , subclinical infection , migraine with aura , cerebellar ataxia , aura , cerebellum , ataxia , neuroscience , medicine , psychology
Mutations in the CACNA1A gene can cause familial hemiplegic migraine (FHM) and/or cerebellar ataxia. CACNA1A codes for the α 1 subunit of P/Q‐Ca 2+ channels and is highly expressed in the cerebellum. Using a pointing paradigm and infrared optoelectronic tracking system, we found subclinical hypermetria and other subtle cerebellar signs in the common forms of migraine. These were more pronounced in migraine with than without aura. Whether this reflects involvement of Ca 2+ channel genes in the common types of migraine needs to be investigated by genetic analyses.