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Seizure‐associated hippocampal volume loss: A longitudinal magnetic resonance study of temporal lobe epilepsy
Author(s) -
Briellmann Regula S.,
Berkovic Samuel F.,
Syngeniotis Ari,
King Mark A.,
Jackson Graeme D.
Publication year - 2002
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10171
Subject(s) - temporal lobe , hippocampal formation , epilepsy , magnetic resonance imaging , hippocampus , medicine , hippocampal sclerosis , central nervous system disease , neuroscience , psychology , radiology
This longitudinal quantitative magnetic resonance imaging study of 24 patients with mild temporal lobe epilepsy shows an ipsilateral hippocampal volume decrease of 9% (range, −30 to +0.5%; p = 0.002, paired t test) over a period of 3.5 ± 0.7 years. The hippocampal volume loss was correlated to the number of generalized seizures between the scans ( p = 0.0007, r = 0.6), suggesting seizure‐associated hippocampal damage.