Premium
Platelet‐derived growth factor‐α receptor‐positive oligodendroglia are frequent in multiple sclerosis lesions
Author(s) -
Maeda Yasuhiro,
Solanky Mukesh,
Mena Joseph,
Chapin John,
Li Weiping,
Dowling Peter
Publication year - 2001
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.1015
Subject(s) - platelet derived growth factor receptor , oligodendrocyte , platelet derived growth factor , biology , multiple sclerosis , progenitor cell , growth factor , population , precursor cell , pathology , receptor , microbiology and biotechnology , cell , immunology , stem cell , neuroscience , central nervous system , medicine , myelin , genetics , environmental health
Platelet‐derived growth factor (PDGF) ligand is a potent glial cell mitogen. When its cognate receptor (PDGF‐αR) is expressed on oligodendroglial lineage cells, such cells are considered capable of division, and the receptor thus serves as a phenotypic marker for oligodendrocyte precursor cells. Here we identify using immunohistochemistry a considerably enlarged, PDGF‐αR‐expressing oligodendrocyte cell population within multiple sclerosis (MS) white matter lesions compared to control brains. Numerous PDGF‐αR‐positive oligodendroglia also colabel heavily with the nuclear cell proliferation marker antibody Ki‐67. Our finding of large numbers of proliferating oligodendroglia in MS brains expressing up‐regulated PDGF‐αR suggests that these progenitor‐like cells represent an important source of regenerating cells for the healing MS lesion.