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Functional recovery and neuroanatomical plasticity following middle cerebral artery occlusion and IN‐1 antibody treatment in the adult rat
Author(s) -
Papadopoulos Catherine M.,
Tsai ShihYen,
Alsbiei Talal,
O'Brien Timothy E.,
Schwab Martin E.,
Kartje Gwendolyn L.
Publication year - 2002
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10144
Subject(s) - neuroplasticity , stroke (engine) , neuroscience , lesion , medicine , forelimb , spontaneous recovery , neurite , stroke recovery , blockade , psychology , rehabilitation , surgery , biology , mechanical engineering , biochemistry , engineering , in vitro , receptor
Abstract Stroke is a prevalent and devastating disorder, and no treatment is currently available to restore lost neuronal function after stroke occurs. One unique therapy that may improve functional recovery after stroke is blockade of the neurite inhibitory protein Nogo‐A with the monoclonal antibody IN‐1, through enhancement of neuroanatomical plasticity from uninjured areas of the central nervous system. In the present study, we combined IN‐1 treatment with an ischemic lesion (permanent middle cerebral artery occlusion) to determine the effect of Nogo‐A neutralization on cortical plasticity and functional recovery. We report here that, following ischemic stroke and treatment with IN‐1, adult rats demonstrated functional recovery on a forelimb‐reaching task and new cortico‐efferent projections from the opposite, unlesioned hemisphere. These results support the efficacy of Nogo‐A blockade as a treatment for ischemic stroke and implicate plasticity from the unlesioned hemisphere as a mechanism for recovery.