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A functional polymorphism in the prodynorphin gene promotor is associated with temporal lobe epilepsy
Author(s) -
Stögmann Elisabeth,
Zimprich Alexander,
Baumgartner Christoph,
AullWatschinger Susanne,
Höllt Volker,
Zimprich Fritz
Publication year - 2002
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10108
Subject(s) - dynorphin , epilepsy , temporal lobe , status epilepticus , promoter , medicine , neuroscience , endocrinology , psychology , biology , genetics , gene , gene expression , opioid peptide , receptor , opioid
The prodynorphin gene ( PDYN ) encoding the anticonvulsant peptide dynorphin is a strong candidate for a seizure suppressor gene and thus a possible modulator of susceptibility to temporal lobe epilepsy. We performed a case control association study in 155 patients with nonlesional temporal lobe epilepsy and 202 controls and found that PDYN promotor low‐expression L‐alleles confer an increased risk for temporal lobe epilepsy in patients with a family history for seizures. Irrespective of the familial background, L‐homozygotes display a higher risk for secondarily generalized seizures and status epilepticus.