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Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms
Author(s) -
Momose Yoshio,
Murata Miho,
Kobayashi Kazuhiro,
Tachikawa Masaji,
Nakabayashi Yuko,
Kanazawa Ichiro,
Toda Tatsushi
Publication year - 2002
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10079
Subject(s) - single nucleotide polymorphism , parkinson's disease , candidate gene , genetics , disease , pathogenesis , genetic association , polymorphism (computer science) , gene , biology , degenerative disease , brain derived neurotrophic factor , genotype , medicine , neurotrophic factors , immunology , receptor
We studied 20 single nucleotide polymorphisms in 18 candidate genes for association with Parkinson's disease. We found that homozygosity for the V66M polymorphism of the brain‐derived neurotrophic factor (BDNF) gene occurs more frequently in patients with Parkinson's disease than in unaffected controls (χ 2 = 5.46) and confirmed an association with the S18Y polymorphism of the UCH‐L1 gene. Our results provide genetic evidence supporting a role for BDNF in the pathogenesis of Parkinson's disease.