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Selective hippocampal neuron loss in dementia with Lewy bodies
Author(s) -
Harding Antony J.,
Lakay Bronwyn,
Halliday Glenda M.
Publication year - 2002
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10071
Subject(s) - subiculum , hippocampal formation , dementia , dementia with lewy bodies , neuroscience , temporal lobe , hippocampus , alzheimer's disease , psychology , pathology , disease , medicine , epilepsy , dentate gyrus
Abstract Hippocampal volume and neuron number were measured using stereological techniques in pathologically confirmed dementia with Lewy bodies (n = 8), Parkinson's disease only (n = 4), and controls (n = 9). We, and others, have previously shown considerable cell loss in the CA1 and subiculum subregions in Alzheimer's disease. In contrast, these regions were spared in dementia with Lewy bodies where a selective loss of lower presubiculum pyramidal neurons was found. These findings suggest a selective loss of frontally projecting hippocampal neurons in dementia with Lewy bodies versus those projecting to temporal lobe regions in Alzheimer's disease.