Open AccessAuto‐brewery syndrome caused by oral fungi and periodontal disease bacteria
Author(s) -
Takahashi Gaku,
Hoshikawa Koichi,
Kan Shigenori,
Akimaru Rise,
Kodama Yoshiyuki,
Sato Toshiro,
Kakisaka Keisuke,
Yamada Yuki
Publication year - 2021
Publication title -
acute medicine and surgery
Language(s) - English
Resource type - Journals
ISSN - 2052-8817
DOI - 10.1002/ams2.652
Subject(s) - candida albicans , alcohol , gastrointestinal tract , medicine , anaerobic bacteria , microbiology and biotechnology , bacteria , gastroenterology , chemistry , biology , biochemistry , genetics
Background Auto‐brewery syndrome (ABS) is often caused by fungi in the intestinal tract. We describe a rare case of alcohol production by Candida albicans and periodontal disease bacteria in the oral cavity. Case Presentation A man aged in his 60s had a car accident, and alcohol was detected on his breath. At the time, he exhibited alcohol overdose seizures with no alcohol consumption. We carried out a gastrointestinal endoscopy, detected esophageal candidiasis, and diagnosed ABS. His seizures continued despite using miconazole oral gel. Significant tooth decay, periodontal disease, and high C. albicans levels were observed in his oral cavity. Alcohol production was confirmed from periodontal bacteria and C. albicans cultures and alcohol‐degrading enzyme functions were poor. Dental treatment and antifungal drugs reduced seizures, and improved his fatty liver. Conclusion Alcohol can be produced by microorganisms in healthy individuals. Therefore, blood alcohol levels and alcohol‐degrading enzyme functions should be examined in patients with unexplained liver dysfunction.