Validating plasminogen activator inhibitor‐1 as a poor prognostic factor in sepsis | Zendy

Hoshino Kota | Zendy; Nakashio Maiko | Zendy; Maruyama Junichi | Zendy; Irie Yuhei | Zendy; Kawano Yasumasa | Zendy; Ishikura Hiroyasu | Zendy

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Validating plasminogen activator inhibitor‐1 as a poor prognostic factor in sepsis

Author(s) -

Hoshino Kota,

Nakashio Maiko,

Maruyama Junichi,

Irie Yuhei,

Kawano Yasumasa,

Ishikura Hiroyasu

Publication year - 2020

Publication title -

acute medicine and surgery

Language(s) - English

Resource type - Journals

ISSN - 2052-8817

DOI - 10.1002/ams2.581

Subject(s) - sepsis , medicine , intensive care unit , fibrinolysis , disseminated intravascular coagulation , gastroenterology , coagulopathy , plasminogen activator inhibitor 1 , organ dysfunction , plasminogen activator , sofa score

Our previous study suggested that plasminogen activator inhibitor‐1 (PAI‐1) levels of ≥83 ng/mL were associated with poor outcomes in patients with sepsis. The results indicate that high PAI‐1 levels (≥83 ng/mL) were associated with increased risks of coagulopathy, organ failure, and mortality. Patients with sepsis and PAI‐1 levels of ≥83 ng/mL tended to develop disseminated intravascular coagulation within 1 week after the sepsis diagnosis.

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