Open AccessValidating plasminogen activator inhibitor‐1 as a poor prognostic factor in sepsis
Author(s) -
Hoshino Kota,
Nakashio Maiko,
Maruyama Junichi,
Irie Yuhei,
Kawano Yasumasa,
Ishikura Hiroyasu
Publication year - 2020
Publication title -
acute medicine and surgery
Language(s) - English
Resource type - Journals
ISSN - 2052-8817
DOI - 10.1002/ams2.581
Subject(s) - sepsis , medicine , intensive care unit , fibrinolysis , disseminated intravascular coagulation , gastroenterology , coagulopathy , plasminogen activator inhibitor 1 , organ dysfunction , plasminogen activator , sofa score
Our previous study suggested that plasminogen activator inhibitor‐1 (PAI‐1) levels of ≥83 ng/mL were associated with poor outcomes in patients with sepsis. The results indicate that high PAI‐1 levels (≥83 ng/mL) were associated with increased risks of coagulopathy, organ failure, and mortality. Patients with sepsis and PAI‐1 levels of ≥83 ng/mL tended to develop disseminated intravascular coagulation within 1 week after the sepsis diagnosis.