Open AccessA rare case of Reye's syndrome induced by influenza A virus with use of ibuprofen in an adult
Author(s) -
Hongo Takashi,
Momoki Noriya,
Mae Souichiro,
Nozaki Satoshi,
Takahashi Kenji,
Fujiwara Toshifumi
Publication year - 2019
Publication title -
acute medicine and surgery
Language(s) - English
Resource type - Journals
ISSN - 2052-8817
DOI - 10.1002/ams2.457
Subject(s) - reye's syndrome , medicine , reye syndrome , ibuprofen , glasgow coma scale , intensive care unit , acetaminophen , fulminant hepatic failure , gastroenterology , hepatic encephalopathy , emergency department , prothrombin time , pediatrics , anesthesia , liver transplantation , cirrhosis , transplantation , psychiatry , pharmacology
Background Reye's syndrome ( RS ) is a rare but severe acute life‐threating disease characterized by encephalopathy and fatty liver damage. Reye's syndrome is most common in children and rarely occurs in adults. Case presentation A 56‐year‐old woman was admitted to the emergency department with disturbance of consciousness and respiratory failure. She had taken ibuprofen for headache. Her Glasgow Coma Scale score was E3V3M5 on admission. The laboratory findings revealed acute liver failure with prothrombin time – international normalized ratio of 3.16, aspartate aminotransferase 12,548 IU /L, alanine aminotransferase 5,725 IU /L, and blood ammonia 102 μg/dL. Head magnetic resonance imaging showed hyperintense signals on diffusion‐weighed images of globus pallidus. We diagnosed the patient with RS induced by influenza A and use of ibuprofen. The patient received supportive care in the intensive care unit and her clinical outcome was favorable. Conclusion Ibuprofen might be a risk factor for RS .