Open AccessContribution of phylogenetics to understanding the evolution and epidemiology of dengue virus
Author(s) -
Yu Xi,
Cheng Gong
Publication year - 2022
Publication title -
animal models and experimental medicine
Language(s) - English
Resource type - Journals
ISSN - 2576-2095
DOI - 10.1002/ame2.12283
Subject(s) - dengue virus , biology , dengue fever , phylogenetic tree , virology , aedes aegypti , phylogenetics , flavivirus , arbovirus , zoology , evolutionary biology , aedes , population , serotype , ecology , virus , genetics , demography , larva , sociology , gene
Dengue virus (DENV) is one of the most important arboviral pathogens in the tropics and subtropics, and nearly one‐third of the world's population is at risk of infection. The transmission of DENV involves a sylvatic cycle between nonhuman primates (NHP) and Aedes genus mosquitoes, and an endemic cycle between human hosts and predominantly Aedes aegypti . DENV belongs to the genus Flavivirus of the family Flaviviridae and consists of four antigenically distinct serotypes (DENV‐1‐4). Phylogenetic analyses of DENV have revealed its origin, epidemiology, and the drivers that determine its molecular evolution in nature. This review discusses how phylogenetic research has improved our understanding of DENV evolution and how it affects viral ecology and improved our ability to analyze and predict future DENV emergence.