Open AccessSuitability of the woodchuck HCC as a preclinical model for evaluation of intra‐arterial therapies
Author(s) -
Kim Alexander Y.,
Yacoub Joseph H.,
Field David H.,
Park Byoung Uk,
Kallakury Bhaskar,
Korolowicz Kyle E.,
Menne Stephan
Publication year - 2020
Publication title -
animal models and experimental medicine
Language(s) - English
Resource type - Journals
ISSN - 2576-2095
DOI - 10.1002/ame2.12100
Subject(s) - medicine , hepatocellular carcinoma , pathological , microsphere , preclinical testing , radiology , embolization , angiography , animal model , pathology , medical physics , chemical engineering , engineering
Abstract The most commonly used preclinical models of hepatocellular carcinoma (HCC) are limited for use in testing of intra‐arterial therapies such as transarterial chemoembolization and radioembolization. Issues encountered with the more commonly used animal models include dissimilarity in their disease development compared with humans and the size of the vasculature which can make intra‐arterial therapy testing difficult or impossible. Here we describe the suitability of the woodchuck HCC model for testing of intra‐arterial therapies. We describe the techniques for pre‐embolization imaging assessment using CT and MRI, technical tips on performing angiography and embolization, and pathological assessment of treated liver.