Open AccessDownregulation of HNRNPK in human cancer cells inhibits lung metastasis
Author(s) -
Li Mengyuan,
Zhang Wenlong,
Yang Xingjiu,
Liu Hongfei,
Cao Lin,
Li Weisha,
Wang Le,
Zhang Guoxin,
Gao Ran
Publication year - 2019
Publication title -
animal models and experimental medicine
Language(s) - English
Resource type - Journals
ISSN - 2576-2095
DOI - 10.1002/ame2.12090
Subject(s) - downregulation and upregulation , lung cancer , metastasis , cancer research , lung , cancer , small hairpin rna , medicine , pathology , rna , biology , gene , biochemistry
Background Lung cancer frequently occurs in the clinic, leading to poor prognosis and high mortality. Markers for early diagnosis of lung cancer are scarce, and further potential therapeutic targets are also urgently needed. Method We established a new mouse model in which the specific gene HNRNPK (heterogeneous nuclear ribonucleoprotein K) was downregulated after administration of doxycycline. The lung metastatic nodules were investigated using bioluminescence imaging, micro‐CT, and autopsy quantification. Results Compared with the short hairpin negative control group, less lung metastatic nodules were formed in the short hairpin RNA group. Conclusion Downregulation of HNRNPK in cancer cells can inhibit lung metastasis.