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Background  The present study covered an assessment of methanolic acetate fractions of  Pistia stratiotes , commonly known as water lettuce, for analgesic, anti‐inflammatory, and  CNS  depressant activities.    Methods  The methanol acetate fractions were extracted from  Pistia stratiotes  and administered to the experimental animals as 200 and 400 mg/kg doses to determine the effect on acetic acid‐induced writhing and formalin‐induced licking and biting, for the assessment of analgesic activity. The anti‐inflammatory assay was done using the carrageenan‐induced hind paw edema method, while assessment of  CNS  depressant activity was done using the open field and hole cross tests. The effects were compared to standard reference drugs.    Results  At both doses (200 and 400 mg/kg body weight), the methanolic acetate extract of  P. stratiotes  showed significant analgesic action ( P  <   0.05) against acetic acid‐induced writhing. The extract was also found to give significant protection against licking and biting at both doses. The methanolic acetate extract of  P. stratiotes  showed a significant ( P  <   0.05) anti‐inflammatory effect from 0 minutes up to 3 hours in the carrageenan‐induced paw edema test. In the  CNS  depressant assay, the methanolic acetate extract showed significant ( P  <   0.05) depressant activity at both doses from 30 to 120 minutes in both the hole cross and open field tests.    Conclusion  Thus we can conclude that  P. stratiotes  extracts have significant analgesic, anti‐inflammatory, and  CNS  depressant activity, compared to standard compounds, in an animal model.

animal models and experimental medicine

An in vivo study of the pharmacological activities of a methanolic acetate fraction of  Pistia stratiotes  L.: An ethno‐medicinal plant used in Bangladesh