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Plasma metabolites associated with cognitive function across race/ethnicities affirming the importance of healthy nutrition
Author(s) -
GranotHershkovitz Einat,
He Shan,
Bressler Jan,
Yu Bing,
Tarraf Wassim,
Rebholz Casey M.,
Cai Jianwen,
Chan Queenie,
Garcia Tanya P.,
Mosley Thomas,
Kristal Bruce S.,
DeCarli Charles,
Fornage Myriam,
Chen GuoChong,
Qi Qibin,
Kaplan Robert,
González Hector M.,
Sofer Tamar
Publication year - 2023
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12786
Subject(s) - mendelian randomization , cognition , generalizability theory , psychology , biology , developmental psychology , genetics , psychiatry , gene , genetic variants , genotype
We studied the replication and generalization of previously identified metabolites potentially associated with global cognitive function in multiple race/ethnicities and assessed the contribution of diet to these associations. Methods We tested metabolite‐cognitive function associations in U.S.A. Hispanic/Latino adults ( n = 2222) from the Community Health Study/ Study of Latinos (HCHS/SOL) and in European ( n = 1365) and African ( n = 478) Americans from the Atherosclerosis Risk In Communities (ARIC) Study. We applied Mendelian Randomization (MR) analyses to assess causal associations between the metabolites and cognitive function and between Mediterranean diet and cognitive function. Results Six metabolites were consistently associated with lower global cognitive function across all studies. Of these, four were sugar‐related (e.g., ribitol). MR analyses provided weak evidence for a potential causal effect of ribitol on cognitive function and bi‐directional effects of cognitive performance on diet. Discussion Several diet‐related metabolites were associated with global cognitive function across studies with different race/ethnicities. Highlights Metabolites associated with cognitive function in Puerto Rican adults were recently identified. We demonstrate the generalizability of these associations across diverse race/ethnicities. Most identified metabolites are related to sugars. Mendelian Randomization (MR) provides weak evidence for a causal effect of ribitol on cognitive function. Beta‐cryptoxanthin and other metabolites highlight the importance of a healthy diet.