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C‐reactive protein levels and risk of dementia—Observational and genetic studies of 111,242 individuals from the general population
Author(s) -
Hegazy Sharif H.,
Thomassen Jesper Qvist,
Rasmussen Ida Juul,
Nordestgaard Børge G.,
TybjærgHansen Anne,
FrikkeSchmidt Ruth
Publication year - 2022
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12568
Subject(s) - c reactive protein , observational study , confidence interval , hazard ratio , medicine , population , dementia , body mass index , disease , demography , environmental health , inflammation , sociology
Increased plasma levels of C‐reactive protein (CRP) in midlife are associated with increased risk of Alzheimer's disease (AD), whereas in older age the opposite association is observed. Whether genetically determined CRP is associated with AD remains unclear. Methods A total of 111,242 White individuals from the Copenhagen General Population Study and the Copenhagen City Heart Study were included. Plasma levels of CRP and four regulatory genetic variants in the CRP gene were determined. Results For CRP percentile group 1 to 5 (lowest plasma CRP) versus the 50 to 75 group (reference), the hazard ratio for AD was 1.69 (95% confidence interval 1.29–2.16). Genetically low CRP was associated with increased risk of AD in individuals with body mass index ≤25 kg/m 2 ( P = 4 × 10 −6 ). Discussion Low plasma levels of CRP at baseline were associated with high risk of AD in individuals from the general population. These observational findings were supported by genetic studies.